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Life extension science: how close are we to longer, healthier lives?

From calorie restriction to cellular reprogramming, scientists are actively exploring how to extend the human lifespan. This article dives into the current state of life extension science, the most promising technologies, and what they could mean for the future of aging.
4 minutes
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May 16 2025
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Longevity
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Life expectancy
Alessia Casali

Aging is the single greatest risk factor for chronic illness, disability, and death. For decades, researchers have studied how biological aging happens — and how we might slow, stop, or even reverse it.

Life extension science doesn’t seek immortality. Instead, it asks:

  • Can we delay aging-related decline?
  • Can we live more years in good health?
  • Can we extend lifespan while preserving quality of life?

Recent breakthroughs suggest the answer may increasingly be yes.

The biology of aging: what we know

Aging is driven by a mix of genetic, cellular, and environmental factors. Hallmarks of aging include:

  • Cellular senescence (damaged cells that no longer divide)
  • Telomere shortening (loss of protective chromosome ends)
  • Mitochondrial dysfunction
  • Accumulation of DNA damage
  • Inflammation and immune system decline

By targeting these processes, scientists aim to treat aging itself as a condition — not just its symptoms.

Key approaches in life extension research

1. Senolytics

These drugs clear out senescent cells, which accumulate with age and contribute to inflammation and tissue damage. In animal models, senolytics have improved heart function and extended lifespan.

2. Caloric restriction and fasting mimetics

Consistently linked to longer life in multiple species. Intermittent fasting and drugs that mimic the effects of caloric restriction (like rapamycin) are under study in humans.

3. NAD+ boosters

NAD+ is a molecule involved in energy metabolism. Its levels decline with age. Boosting it with precursors like NMN or NR may support DNA repair and longevity.

4. Gene editing and epigenetic reprogramming

Techniques like CRISPR and Yamanaka factors are being explored to “reset” cells to a more youthful state. Still in early stages, but conceptually groundbreaking.

5. Stem cell therapy

May one day regenerate damaged tissues or organs. Current research is focused on safety, sourcing, and targeted delivery.

6. Artificial intelligence in aging research

AI is accelerating drug discovery, biomarker identification, and personalized anti-aging interventions by analyzing massive datasets.

Supplements, startups, and skepticism

The growing interest in longevity has led to an explosion of startups offering supplements, therapies, or age-measuring tools. Some are backed by science — others are marketing hype.

Promising areas include:

  • Biological age testing
  • Personalized nutrition based on genetics
  • Wearables tracking metabolic health
  • Peptides and hormone modulators

Caution is warranted. Not all interventions are proven safe or effective. Always consult a healthcare provider.

Ethical questions around life extension

  • Who gets access? Will longevity treatments widen the inequality gap?
  • What about overpopulation? Would longer lives strain resources, or increase wisdom and productivity?
  • How do we redefine old age? If 80 becomes the new 60, how do we think about work, retirement, or death?
  • Do longer lives mean better lives? Or just prolonged suffering?

These are not just scientific questions — they are societal, philosophical, and personal.

Cryopreservation: extending life beyond current limits

While current science focuses on slowing aging, cryopreservation offers a radically different approach: preserving the body after legal death, with the hope of revival when future technology can cure today's terminal illnesses.

At Tomorrow.bio, our cryopreservation protocol includes:

  • Immediate standby and stabilization after legal death
  • Cryoprotectant perfusion to prevent ice damage
  • Vitrification and storage in liquid nitrogen at –196°C
  • Long-term preservation until revival is medically possible

This isn’t life extension in the traditional sense — it’s life continuation when current options run out.

Learn more about our process or book a consultation to explore your options.

What the future may hold

If progress continues, the next few decades could bring:

  • More personalized anti-aging medicine
  • FDA-approved senolytics
  • Safer and more effective stem cell therapies
  • Non-invasive biological age testing
  • Extension of healthy lifespan to 100+ years for more people

Whether through biology or biotechnology, the dream of longer, healthier lives is closer than ever before.

About Tomorrow.bio

At Tomorrow.bio, we are dedicated to advancing the science of cryopreservation with the goal of giving people and pets a second chance at life. As Europe’s leading cryopreservation provider, we focus on rapid, high-quality standby, stabilization, and storage of terminal patients — preserving them until future medical technologies may allow revival and treatment.

📧 Contact us at: hello@tomorrow.bio
🌐 Visit our website: www.tomorrow.bio
🤝 Schedule a consultation: Book a call